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enrofloxacin dosage for goats
STORAGE CONDITIONS: Protect from direct sunlight. ● Exposure within the prior 72 hours to animals showing clinical signs of BRD. 0000001567 00000 n Use within 30 days of first puncture and puncture a maximum of 30 times with a needle or 4 times with a dosage delivery device. Single-Dose Therapy (BRD Treatment): Administer, by subcutaneous injection, a single dose of 7.5-12.5 mg/kg of body weight (3.4-5.7 mL/100 lb). Clinical signs of depression, incoordination and muscle fasciculation were observed in calves when doses of 15 or 25 mg/kg were administered for 10 to 15 days. Mild, transient, post-treatment injection site swellings were observed in pigs receiving the 37.5 mg/kg BW dose. 1. 0000001588 00000 n The effectiveness of Baytril® 100 administered as a single IM dose of 7.5 mg/kg BW for the treatment and control of SRD or as a single SC dose of 7.5 mg/kg BW for the control of colibacillosis was confirmed by demonstrating comparable serum enrofloxacin concentrations following IM or SC injection into the neck of healthy male and female pigs. Should you take probiotics with antibiotics? In such animals, quinolones have, in rare instances, been associated with CNS stimulation which may lead to convulsive seizures. Many goat farmers prefer to use this antibiotic on adult goats, and the usual dosage is 6 cc per 100 pounds of body weight over five consecutive days. The effectiveness of Baytril® 100 for the control of respiratory disease in cattle at high risk of developing BRD was evaluated in a six-location study in the U.S. and Canada. 0000012674 00000 n No clinical signs of toxicity or changes in clinical pathology parameters were observed. Excipients are L-arginine base 200 mg, n-butyl alcohol 30 mg, benzyl alcohol (as a preservative) 20 mg and water for injection q.s. Baytril®100 provides flexible dosages and durations of therapy. If I catch it very early, one dose of penicillin will usually knock it out. Multiple-Day Therapy (BRD Treatment): Administer daily, a subcutaneous dose of 2.5-5 mg/kg of body weight (1.1-2.3 mL/100 lb). Cannot be used but once every 36 hours, because it builds up in vital organs and will cause permanent damage to the animal, including but not limited to ulcerations in the digestive system of the goats. 0000004692 00000 n Refrigerate. Intramuscular Safety: A safety study was conducted in 48 weaned, 20- to 22-day-old pigs. For customer service or to obtain product information, including a Safety Data Sheet, call 1-800-633-3796. Single-Dose Therapy (BRD Control): Administer, by subcutaneous injection, a single dose of 7.5 mg/kg of body weight (3.4 mL/100 lb). 0000005455 00000 n Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. 1. Use Sterile Technique! Cats use with caution. No clinical signs of toxicity were observed when a dose of 5 mg/kg was administered for 15 days. ● Excessive shrink (more than would be expected with a normal load of cattle). Xz�w~N�;+��\p1����a�3��V��?�..g�a��b!��aT��HA�luxb���L��m�RP�~=�#ʸ]�7sa�,�PtJ��K�GVb+0s��fe��fM�z�@�y���Z `��� Q�p6��,��OVSe� �n�AX�������u�(P�l5��p�r�~5�^�tl�p��5�&��?�f�&12�u_�a��C��y0�I�(P�!�Br�2��Cj For treatment of watery mouth disease in neonatal lambs, a single oral dose of 5 to 7 mg/kgbw is administered. 0000014422 00000 n ● A ≥30°F range in temperature fluctuation within a 24-hour period. To prepare the mixture: a. In some Member States, enrofloxacin is authorised for use in sheep, goats and rabbits. Vesicular Stomatitis in Horses and Cattle. For Subcutaneous Use In Beef Cattle And Non-Lactating Dairy Cattle, For Intramuscular Or Subcutaneous Use In Swine, Not For Use In Female Dairy Cattle 20 Months Of Age Or Older Or In Calves To Be Processed For Veal. Baytril® 100 provides flexible dosages and durations of therapy. Common side effects include vomiting, diarrhea, and lack of appetite. `��`�ҍV{�O�X�_�jk.��= endstream endobj 33 0 obj << /Type /Font /Subtype /TrueType /Name /F3 /BaseFont /TimesNewRoman /FirstChar 32 /LastChar 255 /Widths [ 250 333 408 500 500 833 778 180 333 333 500 564 250 333 250 278 500 500 500 500 500 500 500 500 500 500 278 278 564 564 564 444 921 722 667 667 722 611 556 722 722 333 389 722 611 889 722 722 556 722 667 556 611 722 722 944 722 722 611 333 278 333 469 500 333 444 500 444 500 444 333 500 500 278 278 500 278 778 500 500 500 500 333 389 278 500 500 722 500 500 444 480 200 480 541 778 500 778 333 500 444 1000 500 500 333 1000 556 333 889 778 611 778 778 333 333 444 444 350 500 1000 333 980 389 333 722 778 444 722 250 333 500 500 500 500 200 500 333 760 276 500 564 333 760 500 400 549 300 300 333 576 453 250 333 300 310 500 750 750 750 444 722 722 722 722 722 722 889 667 611 611 611 611 333 333 333 333 722 722 722 722 722 722 722 564 722 722 722 722 722 722 556 500 444 444 444 444 444 444 667 444 444 444 444 444 278 278 278 278 500 500 500 500 500 500 500 549 500 500 500 500 500 500 500 500 ] /Encoding /WinAnsiEncoding /FontDescriptor 34 0 R >> endobj 34 0 obj << /Type /FontDescriptor /FontName /TimesNewRoman /Flags 34 /FontBBox [ -250 -216 1152 1000 ] /MissingWidth 320 /StemV 73 /StemH 73 /ItalicAngle 0 /CapHeight 891 /XHeight 446 /Ascent 891 /Descent -216 /Leading 149 /MaxWidth 960 /AvgWidth 401 >> endobj 35 0 obj 562 endobj 36 0 obj << /Filter /FlateDecode /Length 35 0 R >> stream 0000001104 00000 n Goat Notes: Baytril is not recommended for goats, other products such as Nuflor are more effective and show fewer side effects. All pigs remained clinically normal throughout the study. In case of contact, immediately flush eyes with copious amounts of water for 15 minutes. Using an MIC breakpoint of 0.5 mcg ml −1 to obtain an AUIC of 125, an enrofloxacin dose of 32 or 42 mg kg −1 should be administered daily to sheep or goats, respectively. (not Baytril 2.27%). cine for use in goats in the United States (Webb et al. 1-cyclopropyl-7-(4-ethyl-1-piperazinyl)-6-fluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid. Examples of conditions that may contribute to calves being at high risk of developing BRD include, but are not limited to, the following: ● Transportation with animals from two or more farm origins. 0000013152 00000 n For medical emergencies or to report adverse reactions, call 1-800-422-9874. ● Exposure to wet or cold weather conditions. For oral administration: Calves, goats and sheep: Twice daily 10 ml per 75 - 150 kg body weight for 3 - 5 days. Precipitation may occur due to cold temperature. Additional treatments may be given on Days 4 and 5 to animals that have shown clinical improvement but not total recovery. Store at 20-30°C (68-86°F), excursions permitted up to 40°C (104°F). Available for Android and iOS devices. The oral LD50 for laboratory rats was greater than 5000 mg/kg of body weight. In some Member States, enrofloxacin is authorised for use in sheep, goats and rabbits. 0000011716 00000 n 0000012695 00000 n Dosage is 1 cc per 100 lbs IM. Cattle: Animals intended for human consumption must not be slaughtered within 28 days from the last treatment. It is allowed to slaughter animals for meat 10 days after the last application of the preparation. It is rapidly absorbed from the digestive tract, penetrating into all measured body tissues and fluids (See Table III). Baytril®100 may be administered as a single dose for one day for treatment and control of BRD (cattle), for treatment and control of SRD or for control of colibacillosis (swine), or for multiple days for BRD treatment (cattle). It is used for gut-related illnesses and respiratory illnesses such as Pasteurella, not Pnuemonia. �U#Ҽ���0�>�־6dA�j(���� ��W��'f9�߽����=�p}�"��S\�������1.DU�p�j��("7 �ʘ'�%��ȥ�A��#'�bx._�e�0���a#41i%���Rx�xK��R�; oe T$����.���#v�x��� N�:�w�s>�7=T�]2�~�N�Ǩ�@�ߎ��*��屫�|��q���� M�s��� ��������I��[8�1�}o�(��h�'b?�_8��Y�t�FM=�f# Withdrawal notes: Sheep milk: 72 hours, Goats meat and offal: 6 days, Goats milk: 96 hours. The safety and efficacy of this formulation in species other than cattle and swine have not been determined. No articular cartilage lesions were observed after examination of stifle joints from animals administered 25 mg/kg for 15 days. Information contained on this site pertains only to the United States of America, and is not intended to provide adequate information for product use. At each site, when at least 5% of the pigs were defined as “clinically affected” (presence of diarrhea and either depression or gauntness), all pigs were administered Baytril® 100 as a single IM dose of 7.5 mg/kg BW or an equivalent dose volume of saline. Always decontaminate the Baytril vial, NaCl bag port, and NaCl vials with ethanol before inserting a sterile needle, withdrawing compound, or injecting drug. 0000003303 00000 n ● An environmental temperature change of ≥30°F during transportation. Enrofloxacin was administered i.m. Directions: Mix 1 tsp. Otherwise, Baytril, Nuflor, or Draxxin is used depending on the goat and circumstances. If excessive accidental exposure occurs, avoid direct sunlight. Yes, the dosage for Nuflor is 6 cc's/100 lbs for 5 days. In two field studies evaluating effectiveness for treatment of SRD, a total of 300 pigs with clinical signs of SRD (moderate depression, moderately increased respiratory rate, and a rectal temperature of ≥ 104°F) were enrolled and treated with Baytril® 100 or saline. ** Except for the dosage of Pen G, this is label recommendation, which reflect the label withdrawal times. For additional information about adverse drug experience reporting for animal drugs, contact FDA at 1-888-FDA-VETS or online at http://www.fda.gov/AnimalVeterinary/SafetyHealth. Lidocaine Lidocaine extra-label Variable for local anesthesia use, 1% in goats Thiamylal Na Biotal extra-label 10-20 mg/kg IV 1 day 24 hours Xylazine Rompun® extra-label 0.05-0.1 mg/kg IV or IM 5 days 72 hours Yohimbine Yobin extra-label 0.25 mg/kg IV 7 days 72 hours VI. Treatment should be repeated at 24-hour intervals for three days. Bayer HealthCare LLC, Animal Health Division, Shawnee Mission, Kansas 66201 U.S.A. Do not refrigerate or freeze. Cattle were observed daily for clinical signs of BRD and were evaluated for success on Day 14 post-treatment. Only a veterinarian can legally use a … *For 1 mL dose volume from diluted solution. Not for use in humans. 19 0 obj << /Linearized 1 /O 22 /H [ 1318 270 ] /L 31265 /E 23544 /N 3 /T 30767 >> endobj xref 19 37 0000000016 00000 n Swine: Subcutaneous Safety: A safety study was conducted in 32 pigs weighing approximately 57 kg (125 lb) using single doses of 5, 15 or 25 mg/kg daily for 15 consecutive days. 0000006806 00000 n Baytril is the veterinary-labeled form of ciprofloxacin, which is the equivalent drug used for humans. All avian species. The purpose of this work was to perform a radiological study of goat kids submitted to a daily supplementation with enrofloxacin. 0000010965 00000 n Baytril 100 (enrofloxacin) 100 mg/mL Antimicrobial Injectable Solution Indications, Warnings and cautions for Baytril 100 (enrofloxacin) 100 mg/mL Antimicrobial Injectable Solution, Direction and dosage information for Baytril 100 (enrofloxacin) 100 mg/mL Antimicrobial Injectable Solution. ���6< 8'H{���� ���±Q�����_�y&���x������$��x����[�JYuC#��>*�@M�܉�'?��$L�ngHw&H��oTe)r�|��I��ȸ��Ӈ��s/��S�e�! A total of 1,150 crossbred beef calves at high risk of developing BRD were enrolled in the study. The recommended doses are 2.5 to 5 mg enrofloxacin/kg bw/day for 3 to 5 days (cattle and pigs) or 10 mg enrofloxacin/kg bw/day for 3 to 10 days (chicken and turkeys). The effects of enrofloxacin on cattle or swine reproductive performance, pregnancy and lactation have not been adequately determined. The pharmacokinetic disposition of enrofloxacin was studied in goats after subcutaneous (s.c.) administration at a single dose of 7.5 mg/kg body weight. Swine: A total of 590 pigs were treated with Baytril® 100 or saline in two separate natural infection SRD field trials. Each mL of Baytril® 100 contains 100 mg of enrofloxacin. The pharmacokinetic disposition of enrofloxacin was studied in goats after subcutaneous (s.c.) administration at a single dose of 7.5 mg/kg body weight. 0000008904 00000 n Bayer, the Bayer Cross and Baytril are registered trademarks of Bayer. trailer << /Size 56 /Info 17 0 R /Encrypt 21 0 R /Root 20 0 R /Prev 30757 /ID[<3c4f23720fc67f1f5c2399da8c4766ec><3c4f23720fc67f1f5c2399da8c4766ec>] >> startxref 0 %%EOF 20 0 obj << /Pages 18 0 R /Type /Catalog /Outlines 7 0 R >> endobj 21 0 obj << /Filter /Standard /V 1 /R 2 /O (.e�JFt����31��~\nI8'������U� ) /U (Q �M{�6 6V ���2�{ш��nյ\n\n�L��) /P -60 >> endobj 54 0 obj << /S 51 /T 135 /O 180 /Filter /FlateDecode /Length 55 0 R >> stream Treatment of the Scouring Calf. No painful responses to administration were observed. Dosage on bottle is for birds. :�'(B�^����i1�$��`����E�y?T��-�f3�vۚ��f�4:��x�9��o1D)�e Baytril® 100 may be administered as a single dose for one day for treatment and control of BRD (cattle), for treatment and control of SRD or for control of colibacillosis (swine), or for multiple days for BRD treatment (cattle). �rԗbq�y�)z�b�� p*�9@k �g����� �>�/�3�����Б��=����n"�:��E?ɸ-��O�ɓ��hn,�� �����t�ѵ�����x=4���Ƒo���4>�ju!����hUX�͕����䤢���"R���Y�a���E�G���Lic\��ɾI��Hkw�iwJT�8Q�ʴ�~�f�����OZ��ϼ������K���(�����-r��c��0��z����N/�82�2 ��D��� Musculoskeletal stiffness was observed following the 15 and 25 mg/kg treatments with clinical signs appearing during the second week of treatment. Monograph Type: Systemic Drug Drug Class: Fluoroquinolone Antibiotic Trade Name: Baytril® as enrofloksasiini, enrofloxacine, enrofloxacino, enrofloxacinum, Bay-Vp-2674, Baytril ®, Enroflox ®, Enrosite ®, ... to commonly occur. The dosage interval of 48 hours, recommended for calves when an intravenous or subcutaneous dose of 0.5mg/kg is used, is thus likely to be too long for effective treatment of goats. [�����¤�a�d�m�ʢК����;��"����GZw�� �33�m�ڟ�x�#�@T��KR,�Ƃ�:{�H�=��V2_-��'����y4F�(�j�4�6���)E��h�N�^�'�e��Q�"�)q��Tr�/&�n>)�����fs�u�R������R�N�@�d6C!l�A�6�7냤X� �n���7\i��s�P�]��yP��Z>S��߁���o�(�eSS/�� �|t��l}��=8���` D}Q�tmgxm*�}���r���3 endstream endobj 29 0 obj << /Type /FontDescriptor /FontName /Symbol /Flags 6 /FontBBox [ -250 -220 1242 1005 ] /MissingWidth 331 /StemV 109 /StemH 109 /ItalicAngle 0 /CapHeight 1005 /XHeight 503 /Ascent 1005 /Descent -220 /Leading 225 /MaxWidth 1035 /AvgWidth 600 >> endobj 30 0 obj << /Type /Font /Subtype /TrueType /Name /F2 /BaseFont /Symbol /FirstChar 30 /LastChar 255 /Widths [ 600 600 250 333 713 500 549 833 778 439 333 333 500 549 250 549 250 278 500 500 500 500 500 500 500 500 500 500 278 278 549 549 549 444 549 722 667 722 612 611 763 603 722 333 631 722 686 889 722 722 768 741 556 592 611 690 439 768 645 795 611 333 863 333 658 500 500 631 549 549 494 439 521 411 603 329 603 549 549 576 521 549 549 521 549 603 439 576 713 686 493 686 494 480 200 480 549 600 600 600 600 600 600 600 600 600 600 600 600 600 600 600 600 600 600 600 600 600 600 600 600 600 600 600 600 600 600 600 600 600 600 620 247 549 167 713 500 753 753 753 753 1042 987 603 987 603 400 549 411 549 549 713 494 460 549 549 549 549 1000 603 1000 658 823 686 795 987 768 768 823 768 768 713 713 713 713 713 713 713 768 713 790 790 890 823 549 250 713 603 603 1042 987 603 987 603 494 329 790 790 786 713 384 384 384 384 384 384 494 494 494 494 600 329 274 686 686 686 384 384 384 384 384 384 494 494 494 600 ] /FontDescriptor 29 0 R >> endobj 31 0 obj 620 endobj 32 0 obj << /Filter /FlateDecode /Length 31 0 R >> stream In the United States, Enrofloxacin is available by prescription only, meaning that you will need to obtain it through your veterinarian who will prescribe it It has antibacterial activity against a broad spectrum of Gram negative and Gram positive bacteria (See Tables I and II). 0000010677 00000 n 0000001919 00000 n In case of dermal contact, wash skin with soap and water. The pharmacokinetics of enrofloxacin and its active metabolite ciprofloxacin were investigated in goats given enrofloxacin alone or in combination with probenecid. Do not use in calves to be processed for veal. A safety study was conducted in 23-day-old calves using doses of 5, 15 and 25 mg/kg for 15 consecutive days. SQ . In addition, there were more treatment successes (n = 13) than failures (n = 3) in the group of animals positive for M. bovis on Day 0 that were treated with Baytril® 100. Enrofloxacin is an antibiotic given by mouth or in the muscle commonly used to treat bacterial infections in cats, dogs, and off label in small mammals, birds, and reptiles. Baytril (enrofloxacin) Dilution Preparation for Rats . Bar-Guard-99. A two-generation rat reproduction study revealed no effect with 10 mg/kg treatments. Incidental lameness of short duration was observed in all groups, including the saline-treated controls. Injection site inflammation was found on post-mortem examination in all enrofloxacin-treated groups. 2004). The appropriate IM dosage is 4 cc's per 100 lbs. Multiple-day therapy: 2.5 to 5.0 milligrams per kilogram of body weight (1.1 to 2.3 milliliters per 100 pounds) administered subcutaneously once daily for 3 to 5 days. 0000009565 00000 n We comply with the HONcode standard for trustworthy health information -. Treatment success in the Baytril® 100 group (497/573, 87.83%) was significantly higher (P = 0.0013) than success in the saline control group (455/571, 80.92%). Dosage: Goat Notes: Dose orally or mix with drinking water, first dose is double the following four doses. ● Stressful arrival processing procedures (e.g., castration or dehorning). Pigs were administered Baytril® 100, at 7.5, 22.5 and 37.5 mg/kg BW by IM injection into the neck once weekly for 3 consecutive weeks. Enrofloxacin is a broad-spectrum antibiotic used in veterinary medicine to treat animals afflicted with certain bacterial infections. 0000014444 00000 n If you are treating newborn kids, they should have no less than ½ cc. The effectiveness of Baytril® 100 for the control of colibacillosis associated with E. coli was evaluated in a multi-site natural infection field study. Wet Conditions Increase the Chance of Blackleg in Cattle. What I give mine depends on the circumstances. Table 1 - Baytril® 100 Dose and Treatment Schedule for Cattle*. This medication should be refrigerated. The effectiveness of Baytril® 100 administered as a single SC dose of 7.5 mg/kg BW for the treatment and control of SRD associated with M. hyopneumoniae was demonstrated using an induced infection model study and three single-site natural infection field studies. This product is not approved for female dairy cattle 20 months of age or older, including dry dairy cows. Administered dose volume should not exceed 20 mL per injection site. For the treatment of bovine respiratory disease (BRD) associated with Pasteurella haemolytica, P. multocida, and Haemophilus somnus. Penicillin, Benathine (long acting penicillin) No teratogenic effects were observed in rabbits at doses of 25 mg/kg or in rats at 50 mg/kg. Ninety-day feeding studies in dogs and rats revealed no observable adverse effects at treatment rates of 3 and 40 mg/kg respectively. V�z���2�Ƀe2�ARKW�30n7��L���]9 �3��=m��a'7ޕ�����-;�Le�(Mt���:��㗔����g�߳s��,T�v�*����{x�$ܨ��K�|>���ͣ��s�)���L��#�g��A7�oC���L����T�j�#U�M=a#�}Y?~���U8*P�[w�M�a�@6������1�bF�W��4�WOz�����J�mٜa� Swine: 1 litre per 1000 - 3000 litres of drinking water for 3 - 5 days. Transient decreases in feed and water consumption were observed after each treatment. Subcutaneous injection in cattle and swine, or intramuscular injection in swine, can cause a transient local tissue reaction that may result in trim loss of edible tissue at slaughter. Quinolone-class drugs should be used with caution in animals with known or suspected Central Nervous System (CNS) disorders. Usage in goats is "off-label" or "extra-label," but this antibiotic is being used on goats by some veterinarians. Meloxicam has an elimination half-life of 24 hours in cattle, 10.85 hours in sheep, but only 6.73 hours in goats. 0000007525 00000 n No drug-related abnormalities in clinical pathology parameters were identified. Swine: Animals intended for human consumption must not be slaughtered within 5 days of receiving a single-injection dose. Baytril 100 (enrofloxacin) 100 mg/mL Antimicrobial Injectable Solution. There were no clinical signs of toxicity or pathological changes. Swine: Baytril® 100 is indicated for the treatment and control of swine respiratory disease (SRD) associated with Actinobacillus pleuropneumoniae, Pasteurella multocida, Haemophilus parasuis, Streptococcus suis, Bordetella bronchiseptica and Mycoplasma hyopneumoniae. Any product remaining beyond these parameters should be discarded. 0000001318 00000 n per 1 Gallon of water and give for 7 days. Poultry: 1 litre per 1500 - 2000 litres of drinking water for 3 - 5 days. Interflox 100 mg/ml Enrofloxacin 100 ml Gastrointestinal and respiratory infections caused by enrofloxacin sensitive micro-organisms, like Campylobacter, E. coli, Haemophilus, Mycoplasma, Pasteurella and Salmonella spp. How to Use. Antibiotics & Drinking Alcohol - Is it Safe? BRD and mortality were significantly reduced in enrofloxacin-treated calves. No adverse reactions were observed during clinical trials. Blood samples were drawn from a jugular vein into heparinized tubes at predetermined time intervals after administration of the drug and the plasma was separated by centrifugation. See Animal Safety section for additional information. Baytril 100 (Enrofloxacin 100 mg/ml) - Vet prescription. There was no evidence of carcinogenic effect in laboratory animal models. Selection of the appropriate dose and duration of therapy for BRD treatment in cattle should be based on an assessment of the severity of the disease, pathogen susceptibility and clinical response. Selection of the appropriate dose and duration of therapy for BRD treatment in cattle should be based on an assessment of the severity of the disease, pathogen susceptibility and clinical response. Tablets are available in three sizes (22.7, 68.0 and 136.0 mg … in calves, cattle, sheep, goats an Select one or more newsletters to continue. 0000003023 00000 n ONLY . }�k����oA� endstream endobj 55 0 obj 151 endobj 22 0 obj << /Type /Page /Parent 18 0 R /Resources << /Font << /F0 26 0 R /F1 23 0 R /F2 30 0 R /F3 33 0 R /F4 37 0 R >> /XObject << /im1 53 0 R >> /ProcSet 49 0 R >> /Contents [ 28 0 R 32 0 R 36 0 R 40 0 R 42 0 R 44 0 R 46 0 R 48 0 R ] /Thumb 8 0 R /MediaBox [ 0 0 595 842 ] /CropBox [ 0 0 595 842 ] /Rotate 0 >> endobj 23 0 obj << /Type /Font /Subtype /TrueType /Name /F1 /BaseFont /Arial,Italic /FirstChar 32 /LastChar 255 /Widths [ 278 278 355 556 556 889 667 191 333 333 389 584 278 333 278 278 556 556 556 556 556 556 556 556 556 556 278 278 584 584 584 556 1015 667 667 722 722 667 611 778 722 278 500 667 556 833 722 778 667 778 722 667 611 722 667 944 667 667 611 278 278 278 469 556 333 556 556 500 556 556 278 556 556 222 222 500 222 833 556 556 556 556 333 500 278 556 500 722 500 500 500 334 260 334 584 750 556 750 222 556 333 1000 556 556 333 1000 667 333 1000 750 611 750 750 222 222 333 333 350 556 1000 333 1000 500 333 944 750 500 667 278 333 556 556 556 556 260 556 333 737 370 556 584 333 737 552 400 549 333 333 333 576 537 278 333 333 365 556 834 834 834 611 667 667 667 667 667 667 1000 722 667 667 667 667 278 278 278 278 722 722 778 778 778 778 778 584 778 722 722 722 722 667 667 611 556 556 556 556 556 556 889 500 556 556 556 556 278 278 278 278 556 556 556 556 556 556 556 549 611 556 556 556 556 500 556 500 ] /Encoding /WinAnsiEncoding /FontDescriptor 24 0 R >> endobj 24 0 obj << /Type /FontDescriptor /FontName /Arial,Italic /Flags 96 /FontBBox [ -250 -212 1224 1000 ] /MissingWidth 279 /StemV 80 /StemH 80 /ItalicAngle -11 /CapHeight 905 /XHeight 453 /Ascent 905 /Descent -212 /Leading 150 /MaxWidth 1020 /AvgWidth 441 >> endobj 25 0 obj << /Type /FontDescriptor /FontName /Arial /Flags 32 /FontBBox [ -250 -212 1205 1000 ] /MissingWidth 275 /StemV 80 /StemH 80 /ItalicAngle 0 /CapHeight 905 /XHeight 453 /Ascent 905 /Descent -212 /Leading 150 /MaxWidth 1004 /AvgWidth 441 >> endobj 26 0 obj << /Type /Font /Subtype /TrueType /Name /F0 /BaseFont /Arial /FirstChar 32 /LastChar 255 /Widths [ 278 278 355 556 556 889 667 191 333 333 389 584 278 333 278 278 556 556 556 556 556 556 556 556 556 556 278 278 584 584 584 556 1015 667 667 722 722 667 611 778 722 278 500 667 556 833 722 778 667 778 722 667 611 722 667 944 667 667 611 278 278 278 469 556 333 556 556 500 556 556 278 556 556 222 222 500 222 833 556 556 556 556 333 500 278 556 500 722 500 500 500 334 260 334 584 750 556 750 222 556 333 1000 556 556 333 1000 667 333 1000 750 611 750 750 222 222 333 333 350 556 1000 333 1000 500 333 944 750 500 667 278 333 556 556 556 556 260 556 333 737 370 556 584 333 737 552 400 549 333 333 333 576 537 278 333 333 365 556 834 834 834 611 667 667 667 667 667 667 1000 722 667 667 667 667 278 278 278 278 722 722 778 778 778 778 778 584 778 722 722 722 722 667 667 611 556 556 556 556 556 556 889 500 556 556 556 556 278 278 278 278 556 556 556 556 556 556 556 549 611 556 556 556 556 500 556 500 ] /Encoding /WinAnsiEncoding /FontDescriptor 25 0 R >> endobj 27 0 obj 685 endobj 28 0 obj << /Filter /FlateDecode /Length 27 0 R >> stream
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